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Citation: Yang Baokang, Jiang Caihua, Hu Bingfang. SYNTHESIS OF p-BROMOPHENACYL-2, 3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY[J]. Chinese Journal of Applied Chemistry, ;1989, 6(5): 44-46. shu

SYNTHESIS OF p-BROMOPHENACYL-2, 3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY

1.
Institute of Applied Chemistry, Beijing Agricultural University; Institute of Plant Protection, Chinese Agricultural Acadamy, Beijing

Received Date: 30 December 1988
Available Online: 28 March 1989

Some novel p-bromophenacyl-2,3-oxirane carboxylic esters were synthesized by Darzen's condensation and esterification. The compounds were characterized by IR, ¹H NMR spectroscopy and clemental analysis. The antifungal activity of the compounds in vitro has been determined. It is found that, in general, the antifungal activity against Pellicularia Sasakii was higher than that against Macyodhane Kawatasukai and Gibberella Zeae. p-Bromophenacyl-3, 3-pentamethy1ene-2, 3-oxiranepropanoic ester(2), p-bromophenacyl-3-(β-naphthyl)-2,3-oxiranepropanoicester(11) were the most effective which can completely inhibite the mycelial growth of P. Sasakil, M. Kawatsukai in amount of 100 ppm. p-Bromophenacyl-5-methyl-2,3-oxiranehexanoic ester (1) and p-bromophenacyl-3-(p-chlorophenyl)-2, 3-oxiranebutanoic ester(7) were highly active against P.Sasakii.
- p-Bormophenacy1-2,
- 3-oxirane carboxylic esters,
- Antifungal activity,
- Synthesis
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