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Citation: Feng Juncai, Huang Zheyuan, Ni Yaping, Dong Yanhong, Tang Wenxia, Ji Xiujuan, Liu Xiaomei, Wang Longgui. SYNTHESIS, CHARACTERIZATION AND ANTITUMORIGENIC ACTIVITY OF CARBOPLATIN ANALOGUES[J]. Chinese Journal of Applied Chemistry, ;1989, 6(3): 10-14. shu

SYNTHESIS, CHARACTERIZATION AND ANTITUMORIGENIC ACTIVITY OF CARBOPLATIN ANALOGUES

1.
1. Coordination Chemistry Institute, Nanjing University;
2.
2. Institute of Materia Medica, Chinese Academy of Medical Science, Beijing

Received Date: 12 September 1988
Available Online: 24 November 1988

Eighteen new complexes PtA₂X A=NH₃,CH₃NH₂, 1/2 en(ethylenediamine) and 1/2 dmbn 2, 3-dimethy1-2, 3-butanediamine); X=CPrDCA (cyclopropane-1, 1-dicarboxylic acid), 2-M-CPrDCA (2-methyl-cyclopropane-1, 1-dicarboxylic acid), 2-M -CBDCA (2-methyl-cyclobutane-1,1 -dicarboxylic acid),CPDCA (cyclopentane-1, 1-dicarboxylic acid) and CHDCA(cyclohexane-11-dicarboxylic acid))have been synthesized and characterized. It is found that the activities of complexes[Pt(NH₃)₂X] against W-256 in rats are in following order:CPrDCA >2-M-CPrDCA >CPDCA >CBDCA(carboplatin) ≥2-M-CBDCA.
- Platinum complex,
- Carboplatin,
- Antitumor,
- Cycloalkane dicarboxylic acid
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