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Citation: Qu Yun, Tang Wenxia, Hu Hongwen, Dai Anbang, Ji Xiujuan, Zhang Furong, Liu Yu. SYNTHESIS, CHARACTERIZATION AND ANTITUMOUR ACTIVITY OF PLATINUM COMPLEXES OF 1,3-DIAMINOCYCLOHEXANE[J]. Chinese Journal of Applied Chemistry, ;1986, 3(3): 25-29. shu

SYNTHESIS, CHARACTERIZATION AND ANTITUMOUR ACTIVITY OF PLATINUM COMPLEXES OF 1,3-DIAMINOCYCLOHEXANE

Qu Yun ¹ ,
Tang Wenxia ¹ ,
Hu Hongwen ¹ ,
Dai Anbang ¹ ,
Ji Xiujuan ² ,
Zhang Furong ² ,
Liu Yu ²

1.
1. Institute of Coordination Chemistry, Nanjing University;
2.
2. Institute of Materia Medica, Chinese Academy of Medical Science

Received Date: 22 April 1985
Available Online: 12 August 1985

Seven complexes[Pt(1, 3-DACH)X₂] (1, 3-DACH=1, 3-diaminocyclohexane, X=Cl^-,Br^-,(1/2)O_x^2-, (1/2)mal^2-,AC-Cl-, (1/2)SO₄^2-,NO₃^-) have been synthesized and characterized. It is found that[Pt(1, 3-DACH)(AC-CL)₂] has the strongest inhibition effect on L-1210 and S-180 in mice. The relationship between the antitumour activity and structure of the complexes is discussed.
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