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Citation: Shao Weiping, Guan Yintong, Tang Wenxia, Ji Xiujuan. SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF TETRAPLATINUM(Ⅳ) ANALOGUE COMPLEXES[J]. Chinese Journal of Applied Chemistry, ;1992, 9(6): 57-60. shu

SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF TETRAPLATINUM(Ⅳ) ANALOGUE COMPLEXES

1.
1. Institute of Coordination Chemistry, Nanjing University, Nanjing 210008;
2.
2. Institute of Materia Medica, Chinese Academy of Medical Science, Beijing

Received Date: 23 December 1991
Available Online: 18 May 1992

Five tetraplatinum (Ⅳ) analogue complexes were synthesized and characterized, The antitumour activity of the synthesized complexes against S-180 in mice and their water and ethylacetate solubilities were determined, The complex of ???19920612??? was found to have a higher activity, The relationship between the activity of the complexes and their water and ethylacetate solubilities, the mechanism of the action of Pt (Ⅳ)complexes were discussed., Five tetraplatinum (Ⅳ) analogue complexes were synthesized and characterized, The antitumour activity of the synthesized complexes against S-180 in mice and their water and ethylacetate solubilities were determined, The complex of was found to have a higher activity, The relationship between the activity of the complexes and their water and ethylacetate solubilities, the mechanism of the action of Pt (Ⅳ)complexes were discussed., Five tetraplatinum (Ⅳ) analogue complexes were synthesized and characterized, The antitumour activity of the synthesized complexes against S-180 in mice and their water and ethylacetate solubilities were determined, The complex of was found to have a higher activity, The relationship between the activity of the complexes and their water and ethylacetate solubilities, the mechanism of the action of Pt (Ⅳ)complexes were discussed.
- antitumor activity,
- tetraplatinum (Ⅳ) complex,
- S-180 sarcoma
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