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Citation: Hu Chunyan, Zheng Xi, Lin Yuping, Wang Xiuli, Mao Zewei. Syntheses and Cytotoxic Activities of Chalcone Derivatives bearing N-Substituted Piperazine Moiety[J]. Chemistry, ;2016, 79(11): 1089-1092. shu

Syntheses and Cytotoxic Activities of Chalcone Derivatives bearing N-Substituted Piperazine Moiety

Hu Chunyan ¹ ,
Zheng Xi ² ,
Lin Yuping ¹ ,
Wang Xiuli ¹ ,
Mao Zewei ^1,,

1.
1 School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500;
2.
2 Central laboratory, The NO.1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021

Corresponding author: Mao Zewei,
Received Date: 24 April 2016
Available Online: 1 June 2016
Fund Project:

Eight chalcone compounds bearing N-substituted piperazine moiety had been synthesized, and their in vitro cytotoxic activities were evaluated against A549 and SGC7901 by the MTT assay. The structure of target compounds were characterized by¹H NMR, ¹³C NMR and HRMS. The results showed that compounds bearing ketone group show better anticancer activities. In particular, compound 3a was found to be the most potent compound against A549 and SGC7901(IC₅₀=0.28μmol/L and 2.53μmol/L, respectively), so it can be used as a lead compound for further research.
- Chalcone derivatives,
- Synthesis,
- Cytotoxic activity
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