Citation: Shao Yandong, Wang Xianghui, Xie Lingjie, Men Rui, Lin Qiang. Syntheses and Antibacterial Activities of Erucin Derivatives[J]. Chemistry, ;2016, 79(11): 1058-1062. shu

Syntheses and Antibacterial Activities of Erucin Derivatives

1.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158

Corresponding author: Wang Xianghui, Lin Qiang,
Received Date: 18 March 2016
Available Online: 30 May 2016
Fund Project:

Ten erucin analogues were synthesized through substitution, aminolysis, and nucleophilic substitution reaction, starting from N-(2-bromoethyl)phthalimide or N-(4-bromobutyl)phthalimide and sodium hydrosulfide. All of synthesized compounds were tested for their antimicrobial activities in vitro by turbidimetric method against Escherichia coli(DH5a), Staphylococcus aureus(ATCC25923), Staphylococcus albus(ATCC8799), Staphylococcus lutea(ACCC11001), Bacillus subtilis(ATCC6633), Bacillus cereus(ACCC11077) and Micrococcus tetragenus(ATCC35098). The results indicated that all compounds exhibit good antimicrobial activities. Benzyl(2-thiocyanatoethyl)sulfane(5e) and benzyl(4-thiocyanatobutyl)sulfane(5j) showed best inhibitory effects against Escherichia coli(DH5a), with the minimum inhibitory concentration(MIC) of 7.8μg/mL, and excellent inhibitory effects against Staphylococcus aureus(ATCC25923), with the MIC of 15.6μg/mL and 31.2μg/mL.
- Erucin,
- Synthesis,
- Antibacterial activity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142