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Citation: Fu Jianping, Han Xiaodan, Hu Juwu, Wang Huibin, Xiong Wei, Li Xionghui. Papain-Catalyzed Asymmetric Aldol Reactions of Heterocyclic Ketoneswith Aldehydes[J]. Chemistry, ;2016, 79(11): 1052-1057. shu

Papain-Catalyzed Asymmetric Aldol Reactions of Heterocyclic Ketoneswith Aldehydes

1.
Institute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang 330096

Corresponding author: Li Xionghui,
Received Date: 14 April 2016
Available Online: 15 August 2016
Fund Project:

The new promiscuous activity of papain has been observed to catalyze the direct asymmetric Aldol reaction of heterocyclic ketones with aromatic aldehydes. We studied the effects of solvent, water content, ratio of substrates, enzyme loading and temperature on the reaction. Papain showed favorable catalytic activity and had a good adaptability to different substrates in the reaction. Up to 37% yield and 78% ee were achieved under optimal conditions. It is interesting that papain possesses the function of aldolase in organic solvents.
- Biocatalytic promiscuity,
- Papain,
- Aldol reaction,
- Heterocyclic ketones,
- Asymmetric synthesis
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