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Citation: Wu Lihuan, Dong Ji, Chen Zhisheng, Qin Chaoguo. Syntheses and Antibacterial Activities of 3-Substituted Chroman-4-one Derivatives by Solvent-Free Grinding Method[J]. Chemistry, ;2016, 79(11): 1046-1051. shu

Syntheses and Antibacterial Activities of 3-Substituted Chroman-4-one Derivatives by Solvent-Free Grinding Method

1.
School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526060

Received Date: 14 April 2016
Available Online: 30 July 2016
Fund Project:

A series of 3-substituted chroman-4-one derivatives 3a~3t were synthesized by the condensation of 6-halogen(unsubstituted) chroman-4-one with aldehydes in the presence of base by solvent-free grinding method. The structure of the compounds 3a~3t were characterized by IR, ¹H NMR, ¹³C NMR and HRMS. The results of preliminary bioassay showed that most of the tested compounds generally possess good antibacterial activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
- 4-Chromanone,
- Solvent-free,
- Synthesis,
- Antibacterial activity
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