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Citation: Jiang Yaozhong, Ma Youan, Chen Zhenwan, Li Guangnian. SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS Ⅲ.SYNTESIS OF α-METHYL PHENYLALANINE AND THE REACTION OF BENZYLATION[J]. Chinese Journal of Applied Chemistry, ;1987, 4(1): 44-47. shu

SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS Ⅲ.SYNTESIS OF α-METHYL PHENYLALANINE AND THE REACTION OF BENZYLATION

1.
Chengdu Institute of Organic Chemistry, Academia Sinica

Corresponding author: Jiang Yaozhong,
Received Date: 5 November 1985
Available Online: 6 June 1986

This paper reported the synthesis of α-methyl phenylalanine via benzylation of Schiff base (1) derived from alanine methyl ester with benzaldehyde and hydrolysis of (2) using solid-liquid phase transfer catalytic condition.The influencing factors and kinetics of benzylation of Schiff Base have been investigated. It was found that the reaction had the characteristic of surface reaction and autocatalytic reaction. A possible mechanism of solid-liquid phase transfer catalytic alkylation has been proposed.
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