Citation: Wang Xinling, Qu Hai, Sun Demei, Yang jing. Study on the Extraction, Purification and Antitumor Aactivity of Piperine[J]. Chemistry, ;2016, 79(7): 657-661. shu

Study on the Extraction, Purification and Antitumor Aactivity of Piperine

Wang Xinling ¹ ,
Qu Hai ² ,
Sun Demei ¹ ,
Yang jing ^1,,

1.
1. College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046;
2.
2. Zhengzhou Auto Bioengineering Co. Ltd., Zhengzhou 450016

Corresponding author: Yang jing,
Received Date: 3 November 2015
Available Online: 26 February 2016
Fund Project:

In this paper, piperine was extracted from pepper by common solvent extraction method and purified by recrystallization method. Its purity and antitumor activity were characterized. The results showed that the purity of piperine can reach 99.94% and it has a good curative effect on cancer. In addition, the B3LYP method of DFT was used to optimize the structure, relative energy and distribution of the thermodynamic equilibrium of piperine and analysis the theoretical model of piperine. The theoretical models were in good agreement with thermodynamics distribution.
- Piperine,
- Geometrical structure,
- Purification,
- Antitumor activity
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