Citation: Yu Mingkun, Liu Xiangrong, Yan Sen, Yang Zaiwen, Zhao Shunsheng, Yang Shuilan. Syntheses, Characterizations of Acetyl Hydrazone Compounds Containing Halogen Atoms and Their Interaction with ct-DNA[J]. Chemistry, ;2016, 79(7): 616-622. shu

Syntheses, Characterizations of Acetyl Hydrazone Compounds Containing Halogen Atoms and Their Interaction with ct-DNA

1.
Xi'an University of Science and Technology, College of Chemistry and Chemical Engineering, Xi'an 710054

Corresponding author: Liu Xiangrong,
Received Date: 2 December 2015
Available Online: 3 March 2015
Fund Project:

4-Hydroxy phenylacetyl hydrazine was synthesized by methyl 4-hydroxyphenylacetate and hydrazine hydrate, then reacted with halogenated benzaldehyde (X=F, Cl, Br) to form three new kinds of compoundsⅠ,Ⅱ and Ⅲ. Their single crystals were respectively obtained. The structures of three new compounds were determined by element analysis and X-ray single crystal diffraction. The X-ray single crystal diffraction showed that three new compounds all belonged to the triclinic, P1 space group, and each molecular staggered to pile up through hydrogen bond. Thermal gravity analyses were used to investigate the stabilities of three new compounds, and the apparent activation energy E_a of the decompositions were also calculated. UV-Vis spectrum was used to explore the interaction of the three kinds of compounds with ct-DNA. The results showed that the three acetyl hydrazone compounds can combine with ct-DNA by the mode of insertion. The heating effects of the interaction process between compounds and ct-DNA were also analyzed by microcalorimetric method, the enthalpy change values ΔH of Ⅰ、Ⅱ and Ⅲ were 1.87, 2.86 and 5.54 kJ·mol^-1. The strength order for interactions of compounds with ct-DNA was Ⅲ >Ⅱ >Ⅰ. CCDC:1402717, Ⅰ; 1063026, Ⅱ; 1061929, Ⅲ.
- Acyl hydrazone,
- Crystal structure,
- Thermal stability,
- Microcalorimetric,
- ct-DNA
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