Citation: Hu Xiangzheng, Feng Yaya. Progress in the Preparation and Anti-Tumor Effect of Betulinic Acid and Its Derivatives[J]. Chemistry, ;2016, 79(7): 589-596. shu

Progress in the Preparation and Anti-Tumor Effect of Betulinic Acid and Its Derivatives

Hu Xiangzheng ^1,2 ,
Feng Yaya ¹

1.
1. College of Food Engineering and Biological Technology, Tianjin University of Science & Technology, Tianjin 300457;
2.
2. College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, Tianjin 300457

Received Date: 27 September 2015
Available Online: 3 March 2016
Fund Project:

Betulinic acid as a kind of pentacyclic triterpenoid lupine has caught wide attention due to the significant anti-tumor and anti-HIV viral properties. Betulinic acid existing in many plants can be obtained by extraction method. Because of the low content in plants, betulinic acid is obtained mainly by chemical synthesis. A series of betulinic acid derivatives also have antitumor activity. In this paper, both extraction and chemical synthesis methods of betulinic acid as well as the synthetic routes of betulinic acid derivatives are reviewed. The anti-tumor pathways and mechanisms of betulinic acid and its derivatives are also outlined.
- Betulinic acid,
- Preparation,
- Chemical modification,
- Antitumor
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