Citation: Xu Xiaofan, Li Runtu, Li Mengmeng, Li Duanhua, Chen Chunyan, Luo Zhongli. Preliminary Study on Monitor Real-Time by using Self-Assembling Peptide Nanomaterials[J]. Chemistry, ;2016, 79(6): 516-522. shu

Preliminary Study on Monitor Real-Time by using Self-Assembling Peptide Nanomaterials

1.
1. The College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016;
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2. The First Affiliated hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400016;
3.
3. Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610051;
4.
4. The Cardiology Third Ward, Zhengzhou People's Hospital, Zhengzhou 450000

Corresponding author: Luo Zhongli,
Received Date: 13 October 2015
Available Online: 6 January 2016
Fund Project:

The secondary structure, nanostructure and macro-feature of peptide GFS-15 were characterized by circular dichroism spectroscopy (CD), AFM and Congo red dye. The influence of concentration, self-assembly time and ions on the self-assembly process of the peptide were studied by cyclic voltammetry (CV) and CD. The results showed that this peptide can form nano-fiber which can bind to gold electrode to form the hydrogel support 3D cell culture matrix. 3D cell culture test and 3D cell culture real-time tests confirmed the cell strain not only growth in the nano 3D microenvironment, but also self-assembling to gold electrode sensor (nano-gold particles) surface. This study may inspire cell real-time monitor and nano-biomedical developing.
- GFS-15 peptide,
- Self-assembly,
- CD,
- Cyclic voltammetry,
- Nano-fiber
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沈阳化工大学材料科学与工程学院沈阳 110142