Citation: Liu Weiwei, Cheng Fengchang, Yin Long, Li Quxiang. Syntheses of D-Glucosamine Acylthiourea Derivatives[J]. Chemistry, ;2016, 79(1): 77-82,76. shu

Syntheses of D-Glucosamine Acylthiourea Derivatives

1.
1. Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005;
2.
2. College of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116;
3.
3. Jiangsu Institute of Marine Resources, Lianyungang 222005

Received Date: 18 May 2015
Available Online: 13 July 2015
Fund Project:

Twelve kinds of D-glucosamine acylthiourea derivatives were synthesized from acyl isothiocyanate and 1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucosamine hydrochloride prepared from D-glucosamine hydrochloride by protection of amino group followed by acetylation of hydroxyl group, and deprotection of the amino group. The optimal conditions for the coupling reaction were the molar ratio of acyl isothiocyanate and 1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucosamine 1:1.2 in dichloromethane at 40℃ for 6 hours. The products were characterized by IR, ¹H NMR and ¹³C NMR.
- D-glucosamine,
- Acylthiourea,
- Synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142