Citation: Yang Wanli, Su Zhaoxuan, Chen Lin, Wang Qingwen. Study on the Synthesis and Safety of Long Chain Quaternary Ammonium Salt with Vinyl Benzyl[J]. Chemistry, ;2016, 79(1): 56-61. shu

Study on the Synthesis and Safety of Long Chain Quaternary Ammonium Salt with Vinyl Benzyl

1.
1. College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006;
2.
2. MOE Key Laboratory of Bio based Material Science and Technology, Northeast Forestry University, Harbin 150040

Received Date: 7 May 2015
Available Online: 10 August 2015
Fund Project:

In this paper, 1-(chloromethyl)-4-vinylbenzene (C₉H₉Cl) as raw material, a new type quaternary ammonium salt antibacterial monomer, namely C₉H₉Cl-16DMA, was synthesized through nucleophilic substitution reaction with N,N-dimethylcetylamine (16DMA), and its structure was characterized by using FT IR, ¹H NMR, EA, TG. Its antibacterial activities were tested for staphylococcus aureus, bacillus subtilis and escherichia coli by the inhibition zone method. Considering the future application and safety, its toxicity was evaluated. The results showed that there were no abnormal change in the physiological characteristics and the skin of rabbit, and the scope of LD₅₀ was 3000.68(2560.57~3440.79) mg/kg calculated by Karber's method.
- Quatemary ammonium salt,
- Synthesis,
- Antibacterial mechanism,
- Safety
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沈阳化工大学材料科学与工程学院沈阳 110142