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Citation: Kuang Yu, Xu Qigui. Improved Synthesis of Betrixaban[J]. Chemistry, ;2016, 79(3): 276-278. shu

Improved Synthesis of Betrixaban

Kuang Yu ,
Xu Qigui ^,

1.
Pharmacy College, Chongqing Medical University, Chongqing 400016

Corresponding author: Xu Qigui,
Received Date: 26 August 2015
Available Online: 12 October 2015

Betrixaban was synthesized from 5-methoxy-2-nitrobenzoic acid through hydrogenation, acylation and nucleophilic addition reaction with dimethylamine in an overall yield of 61%. The synthetic route has the advatages of easy to operate, mild conditions and high yield, it has a good prospect in industrial application.
- Betrixaban,
- Hydrogenation,
- Synthesis
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