Citation: Zheng Chenglong, Liu Yizhou, Kang Congmin. The Improvement of Synthesis of 3-Aminoindolin-2-one[J]. Chemistry, ;2016, 79(5): 463-465. shu

The Improvement of Synthesis of 3-Aminoindolin-2-one

1.
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042

Corresponding author: Kang Congmin,
Received Date: 8 September 2015
Available Online: 18 January 2016
Fund Project:

The titled compound was synthesized by the hydrogenation reduction of 3-(hydroxyimino) indolin-2-one, which was synthesized by the reaction of isatin and hydroxylamine hydrochloride. Using Pd/C hydrogenation reduction method, the product yield can be increased to 82.8%, higher than the 71.0% reported in literature. The synthesis has the advantages of high yield, good operability, easy post-processing, low cost and environmental benign, so it is suitable for mass production of the titled compound.
- Aniline,
- Hydroxylamine hydrochloride,
- Isatin,
- Palladium hydrogenation,
- 3-Aminoindolin-2-one
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沈阳化工大学材料科学与工程学院沈阳 110142