Citation: Zhang Suihong, Xie Zongbo, Yang Xiaoli, Le Zhanggao. Synthesis of Tetrahydrothiophene Derivatives by Enzymatic Cascade Michael-Aldol Reaction[J]. Chemistry, ;2016, 79(8): 768-770. shu

Synthesis of Tetrahydrothiophene Derivatives by Enzymatic Cascade Michael-Aldol Reaction

1.
Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Corresponding author: Xie Zongbo, Le Zhanggao,
Received Date: 14 January 2016
Available Online: 3 March 2016
Fund Project:

Tetrahydrothiophene derivatives were synthesized from the Michael-aldol reaction of 1,4-dithiane-2,5-diol and N-phenyl maleimide in water using alkaline protease as a promiscuous catalyst, the yield of 93% and the dr of 3:1 were obtained at 40℃. This method has the advantages of mild reaction conditions, short reaction time, simple post-processing, etc.
- Alkaline protease,
- Biocatalysis,
- Diastereoselectivity,
- Tetrahydrothiophene
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