Citation: Liang Yong, Wang Xiang, Zhou Xiaohu, Li Jiaqi, Xu Hai. Research Development of α-Helix Mimetics Based on Aromatic Oligoamides[J]. Chemistry, ;2016, 79(8): 719-722. shu

Research Development of α-Helix Mimetics Based on Aromatic Oligoamides

  • Corresponding author: Xu Hai, 
  • Received Date: 17 December 2015
    Available Online: 22 April 2016

  • α-Helix mimetics are an important class of small molecule inhibitors of protein-protein interactions. Small molecular α-helix mimetics derived from aromatic oligoamides have many advantages and achieved rapid development in recent years. The latest progress of α-helix mimetics based on aromatic oligoamides was reviewed.
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    1. [1]

      [1] W E Stites. Chem. Rev., 1997, 97(5): 1233~1250.

    2. [2]

      [2] O Keskin, A Gursoy, B Y Ma et al. Chem. Rev., 2008, 108(4): 1225~1244.

    3. [3]

      [3] T K Lee, J M Ahn. ACS Comb. Sci., 2011, 13(2):107~111.

    4. [4]

      [4] F Ruan, Y Chen, P B Hopkins. J. Am. Chem. Soc., 1990, 112(25), 9403~9404.

    5. [5]

      [5] I S Moreira, P A Fernandes, M J Ramos. Proteins, 2007, 68(4): 803~812.

    6. [6]

      [6] H Yin, G I Lee, K A Sedey et al. J. Am. Chem. Soc., 2005, 127(15): 5463~5468.

    7. [7]

      [7] A J Wilson. Prog. Biophys. Mol. Bio., 2015, 119(1): 33~40.

    8. [8]

      [8] D W Zhang, X Zhao, J L Hou et al. Chem. Rev., 2012, 112(10): 5271~5316.

    9. [9]

      [9] M K P Jayatunga, S Thompson, A D Hamilton. Bioorg. Med. Chem. Lett., 2014, 24(3): 717~724.

    10. [10]

      [10] J S Nowick. Acc. Chem. Res., 2008, 41(10): 1319~1330.

    11. [11]

      [11] B Gong. Chem. Eur. J., 2001, 7(20): 4336~4342.

    12. [12]

      [12] I Huc. Eur. J. Org. Chem., 2004, 35: 17~29.

    13. [13]

      [13] P Prabhakaran, A Barnard, N S Murphy et al. Ann. Chem. Pharma., 2013, 19: 5546~5550.

    14. [14]

      [14] J P Plante, T Burnley, B Malkova et al. Chem. Commun., 2009, 5091~5093.

    15. [15]

      [15] B P Orner, J T Ernst, A D Hamilton. J. Am. Chem. Soc., 2001, 123(22):5382~5383.

    16. [16]

      [16] D T Chao, S J Korsmeyer. Annu. Rev. Immunol., 1998, 16(1): 395~419.

    17. [17]

      [17] O Kutzki, H S Park, J T Ernst et al. J. Am. Chem. Soc., 2002, 124(40): 11838~11839.

    18. [18]

      [18] J H Lee, Q Zhang, S Jo et al. J. Am. Chem. Soc., 2011, 133(4): 676~679.

    19. [19]

      [19] J T Ernst, J Becerril, H S Park et al. Angew. Chem., 2003, 115(5): 553~557.

    20. [20]

      [20] J L Yap, X Cao, K Vanommeslaeghe et al. Org. Biomol. Chem., 2012, 10: 2928~2933.

    21. [21]

      [21] P H Kussie, S Gorina, V Marechal et al. Science, 1996, 274: 948~953.

    22. [22]

      [22] P Prabhakaran, V Azzarito, T Jacobs et al. Tetrahedron, 2012, 68(23):4485~4491.

    23. [23]

      [23] A Shaginian, L R Whitby, S Hong et al. J. Am. Chem. Soc., 2009, 131(15):5564~5572.

    24. [24]

      [24] K Khoury, G M Popowicz, T A Holak et al. Med. Chem. Commun., 2011, 2: 246~260.

    25. [25]

      [25] L Romer, C Klein, A Dehner. Angew. Chem. Int. Ed., 2006, 45(39): 6440~6460.

    26. [26]

      [26] R E W Hancock, A Rozek. FEMS Microbiol. Lett., 2002, 206: 143~149.

    27. [27]

      [27] S Thompson, R Vallinayagam, M J Adler et al. Tetrahedron, 2012, 68(23): 4501~4505.

    28. [28]

      [28] F Campbell, J P Plante, T A Edwards et al. Org. Biomol. Chem., 2010, 8: 2344~2351.

    29. [29]

      [29] J C Fuller, R M Jackson, T A Edwards et al. PloS One, 2012, 7: 103~110.

    30. [30]

      [30] D M Engelman, T A Steitz. Cell, 1981, 23(2): 411~422.

    31. [31]

      [31] J Deville, J Rey, M Chabbert. Proteins, 2008, 72(1): 115~135.

    32. [32]

      [32] O V Kulikov, S Thompson, H Xu et al. Eur. J. Org. Chem., 2013, 17: 3433~3445.

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