Citation: Liu Weiwei, Liu Xiujian, Yin long, Cheng Fengchang. Progress in Syntheses and Biological Activities of 1,3,4-Thiadiazole Derivatives[J]. Chemistry, ;2016, 79(10): 929-935,941. shu

Progress in Syntheses and Biological Activities of 1,3,4-Thiadiazole Derivatives

1.
1. Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005;
2.
2. Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Lianyungang 222005;
3.
3. Jiangsu Institute of Marine Resources, Lianyungang 222005;
4.
4. Chemical Engineering Institute, China University of Mining and Technology, Xuzhou 221116

Received Date: 11 January 2016
Available Online: 28 May 2016
Fund Project:

1,3,4-thiadiazole is five-membered heterocyclic compound which contains heteroatoms of N and S, having a variety of biological activities. The derivatives of 1,3,4-thiadiazole have been applied to the fields of biology, medicine and others, and have made breakthrough in such aspects as antibacterial, antitumor, and anticancer research. It is of great significance to research on its derivatives due to special structure and superior biological activities. This article has a closer look at the synthesis methods and the research of antibacterial, antitumor, anticancer of the derivatives of 1,3,4-thiadiazole.
- 1,3,4-Thiadiazole,
- Derivatives,
- Synthesis methods,
- Biological activity
1. [1]
  [1] Y Hu, C Y Li, X M Wang et al. Chem. Rev., 2014, 114:5572~5610.
2. [2]
  [2] H M Kuo, S Y Li, H S Sheu et al. Tetrahedron, 2012, 68(36):7331~7337.
3. [3]
  [3] D Kumar, N M Kumar, K H Chang et al. Eur. J. Med. Chem., 2010, 45(10):4664~4668.
4. [4]
  [4] C T Liao, Y J Wang, C S Huang et al. Tetrahedron, 2007, 63(50):12437~12445.
5. [5]
  [5] J K Augustine, V Vairaperumal, S Narasimhan et al. Tetrahedron, 2009, 65(48):9989~9996.
6. [6]
  [6] M X Wei, L Feng, X Q Li et al. Eur. J. Med. Chem., 2009, 44(8):3340~3344.
7. [7]
  [7] A A Kadi, E S Al-Abdullah, I A Shehata et al. Eur. J. Med. Chem., 2010, 45(11):5006~5011,
8. [8]
  [8] G Rai, V Kenyon, A Jadhav et al. J. Med. Chem., 2010, 53(20):7392~7404.
9. [9]
  [9] Y Luo, S Zhang, Z J Liu et al. Eur. J. Med. Chem., 2013, 64:54~61.
10. [10]
  [10] A T Mavrova, D Wesselinova, J A Tsenov et al. Eur. J. Med. Chem., 2014, 86:676~683.
11. [11]
  [11] K R Sathisha, S A Khanum, J N N S Chandra et al. Bioorg. Med. Chem., 2011, 19:211~220.
12. [12]
  [12] J K Jiang, J G McCoy, M Shen et al. Bioorg. Med. Chem., 2014, 24:1148~1153.
13. [13]
  [13] M N Noolvi, H M Patel, N Singh et al. Eur. J. Med. Chem., 2011, 46(9):4411~4418.
14. [14]
  [14] G L Almajan, S F Barbuceanu, G Bancescu et al. Eur. J. Med. Chem., 2010, 45(12):6139~6146.
15. [15]
  [15] F Aryanasab, A Z Halimehjani, M R Saidi. Tetrahed. Lett., 2010, 51(5):790~792.
16. [16]
  [16] U Salgm-Goksen, N Gokhan-Kelekci, O Goktas et al. Bioorg. Med. Chem., 2007, 15(17):5738~5751.
17. [17]
  [17] K Matsuno, Y Masuda, Y Uehara et al. ACS Med. Chem. Lett., 2010, 1(8):371~375.
18. [18]
  [18] T T Wang, W K Miao, S S Wu et al. Chin. J. Chem., 2011, 29(5):959~967.
19. [19]
  [19] M D Hall, N K Salam, J L Hellawell et al. J. Med. Chem., 2009, 52(10):3191~3204.
20. [20]
  [20] A A Hassan, A F E Mourad, K M El-Shaieb et al. Molecules, 2005, 10(7):822~832.
21. [21]
  [21] A A Hassan, A F E Mourad, K M El-Shaieb et al. Heteroatom Chem., 2003, 14(6):535~541.
22. [22]
  [22] J M Farrar, M K Patel, P Kaszynski et al. J. Org. Chem., 2000, 65(4):931~940.
23. [23]
  [23] A R Sayed. Tetrahed. Lett., 2010, 51(34):4490~4493.
24. [24]
  [24] A S Shawali, A R Sayed. J. Sulfur Chem., 2006, 27(3):233~244.
25. [25]
  [25] A S Shawali, A R Sayed. J. Sulfur Chem., 2007, 28:23~29.
26. [26]
  [26] M A Epishina, A S Kulikov, N V Ignat'ev et al. Mendeleev Commun., 2011, 21(6):331~333.
27. [27]
  [27] M E Layton, M J Kelly, K J Rodzinak et al. ACS Chem. Neurosci., 2011, 2(7):352~362.
28. [28]
  [28] J Matysiak, A Skrzypek, A Niewiadomy. Heteroatom Chem., 2010, 21(7):533~540.
29. [29]
  [29] V Padmavathi, G D Reddy, S N Reddy et al. Eur. J. Med. Chem., 2011, 46(4):1367~1373.
30. [30]
  [30] V Padmavathi, G S Reddy, A V N Mohan et al. ARKIVOC, 2008:48~60.
31. [31]
  [31] J C Kappel, T S Yokum, G Barany. J. Comb. Chem., 2004, 6:746~752
32. [32]
  [32] J Y Hwang, H S Choi, D H Lee et al. J. Comb. Chem., 2005, 7:816~819.
33. [33]
  [33] Y D Gong, T Lee. J. Comb. Chem., 2010, 12(4):393~409.
34. [34]
  [34] V Polshettiwar, R S Varma. Tetrahed. Lett., 2008, 49(5):879~883.
35. [35]
  [35] A A Kiryanov, P Sampson, A J Seed. J. Org. Chem., 2001, 66(23):7925~7929.
36. [36]
  [36] 李政, 田国强, 赵彦龙. 西北师范大学学报(自然科学版), 2008, 44(3):46~49.
37. [37]
  [37] 刘玮炜, 霍云峰, 张强. 华侨大学学报(自然科学版), 2013, 34(5):539~541.
38. [38]
  [38] V Mathew, J Keshavayya, V P Vaidya et al. Eur. J. Med. Chem., 2007, 42(6):823~840.
39. [39]
  [39] B Chandrakantha, A M Isloor, P Shetty et al. Eur. J. Med. Chem., 2014, 71:316~323.
40. [40]
  [40] M N Noolvi, H M Patel, S Kamboj et al. Arab. J. Chem., 2012, 2:003.
41. [41]
  [41] S Talath, A K Gadad, Eur. J. Med. Chem., 2006, 41(8):918~924.
42. [42]
  [42] 王美君, 卢俊瑞, 辛春伟等. 高等学校化学学报, 2015, 36:469~476.
43. [43]
  [43] 李英俊, 孙亚珍, 靳焜等. 有机化学, 2008, 28:1074~1078.
44. [44]
  [44] Z Luo, B Chen, S Y He et al. Bioorg. Med. Chem. Lett., 2012, 22(9):3191~3193.
45. [45]
  [45] D A Ibrahim. Eur. J. Med. Chem., 2009, 44(7):2776~2781.
46. [46]
  [46] W Rzeski, J Matysiakb, M K Szerszen et al. Bioorg. Med. Chem., 2007, 15(9):3201~3207.
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