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Citation: HE Huai-Zhen, LI Jian-Li, WU Xiang-Long, Wang Lu-Yao, SHI Zhen. Biomimetic Synthesis of 1-Naphthyl Cyclohexyl Ketone[J]. Chinese Journal of Applied Chemistry, ;2006, 23(6): 685-687. shu

Biomimetic Synthesis of 1-Naphthyl Cyclohexyl Ketone

1.
Department of Chemistry, Northwest University, Xi'an 710069

Corresponding author: SHI Zhen,
Received Date: 10 August 2005
Available Online: 10 February 2006
Fund Project: 国家自然科学基金(20472067) (20472067)

Based on the one-carbon unit transfer reaction of tetrahydrofolate coenzymes,α-naphthyl cyclo-hexyl ketone was synthesized successfully with benzoimidazolium salt as the tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transferred via addition-hydrolysis reaction.This provides a new convenient biomimetic synthesis method to the title compound.The α-naphthyl cyclohexyl ketone was characterized by means of IR spectra,MS and ¹H NMR.The reaction mechanism and the effects of reaction conditions on the yield were investigated.
- tertrahydrofolate coenzyme,
- benzoimidazolium salt,
- Grignard reagent,
- α-naphthyl cyclohexyl ketone,
- biomimetic synthesis
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