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Citation: Shi Haijian, Wang Zhongy yi, Shi Haoxin. Synthesis and Biological Activity of 2, 5-Disubstituted-2, 3-dihydrogen-1, 2,4-triazolo[3, 4-b]-1, 3, 4-thiadiazoles[J]. Chinese Journal of Applied Chemistry, ;1999, 16(5): 53-56. shu

Synthesis and Biological Activity of 2, 5-Disubstituted-2, 3-dihydrogen-1, 2,4-triazolo[3, 4-b]-1, 3, 4-thiadiazoles

1.
a Department of Chemistry, Anhui Normal University, Wuhu 241000;
2.
b Department of Chemist ry, China University of Science and Technology, Hefei

Received Date: 8 March 1999
Available Online: 24 May 1999
Fund Project:

Seventeen novel fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenyl/m-nitrophenyl/-4-amino-5-mercapto 1,2,4 triazoles with aldehydes in the pre sence of hydrochloric acid at 80℃ for 10 h. The reaction conditions and catalysts have been in vestigated. The structures of the compounds have been confirmed by elemental analysis, IR, ¹H NMR and MS measurements. The preliminary tests showed they display some antibaterial ac tivities.
- arylaminomercaptotriazole,
- Mannich reaction,
- synthesis,
- biological activity
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