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Citation: YAN Jun, ZHOU Chun-Cai. Swelling and Drug Release Behavior of pH-Sensitive Cationic Polyelectrolyte Gels[J]. Chinese Journal of Applied Chemistry, ;2000, 17(1): 75-77. shu

Swelling and Drug Release Behavior of pH-Sensitive Cationic Polyelectrolyte Gels

YAN Jun ,
ZHOU Chun-Cai

1.
Department of Chemistry, East-China Normal University, Shanghai 200062

Received Date: 27 April 1999
Available Online: 14 October 1999

A series of pH-sensitive cationic polyelectrolyte gel beads were prepared by suspension copolymerization of styrene or methyl methacrylate with diethylaminoethyl methacry late and divinylbenzene. The study on the swelling behavior of the gels showed that the hydrophobic/hydrophilic composition of the gels had a great influence on the phase transition pH value and the swelling ability of the gels. Both the equilibrium swelling capacity and the swelling rate were pH dependent. The drug release behavior of the gels were well correlated with the swelling behavior of the gels.
- copolymer,
- cationic polyelectrolyte gel,
- swelling,
- drug release
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