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Citation: ZHAO Di-Shun, SHI Lan-Xiang, XU Zhi-Dong, CHEN Huan-Zhang, RONG Jie. Preparation of 7-(Phenylacetamido)deacetoxycephalosporin Acid via Catalytic Ring-Expansion of Penicillin G Sulfoxide[J]. Chinese Journal of Applied Chemistry, ;2000, 17(3): 346-348. shu

Preparation of 7-(Phenylacetamido)deacetoxycephalosporin Acid via Catalytic Ring-Expansion of Penicillin G Sulfoxide

1.
Department of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018

Received Date: 11 November 1999
Available Online: 26 January 2000
Fund Project: 河北省科委资助项目(97213052D) (97213052D)

The 7-(phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N'-dimethylsilylurea) using HBr-4-methylpyridine as catalyst. The effects of catal-yst amount, reaction temperature and time were examined. Under optimum reaction condi tions product in 94% yield was obtained. The product has been characterized by IR and MS.
- phenylacetamido-deacetoxycephalosporin acid,
- penicillin G sulfoxide,
- protective silylation,
- catalytic ring expansion,
- preparation
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