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Citation: MOU Li-Juan, JIANG Wen-Wei, XIA Su-Lan. Chloromethylation of 1,3-Benzodioxole in the Presence of Micellar Catalysts[J]. Chinese Journal of Applied Chemistry, ;2000, 17(5): 563-565. shu

Chloromethylation of 1,3-Benzodioxole in the Presence of Micellar Catalysts

1.
Department of Chemical Engineering, Sichuan University, Chengdu 610065

Received Date: 30 December 1999
Available Online: 1 June 2000

1,3-Benzodioxole was monochloromethylated directly by aqueous formaldehyde and hydrogen chloride gas in CCl₄ in the presence of quaternary ammonium salts:C₁₆H₃₃-(CH₃)₃ NX(X=Br,Cl), C₁₂H₂₅(CH₃)₃ NCl,C₁₂H₂₅(CH₃)₂(C₆H₅CH₂)NCl and (C₄H₉)₄ NBr. With hexadecyltrimethylammonium bromide at temperature 60~65℃ and for 15 hours of reaction, 1,3-benzodioxole was converted to piperonyl chloride with conversion more than 98% and selectivity up to 97%. The method has advantages of high selectivity, high conversion, negligible by-products and easy workup of the main product.
- benzodioxole,
- chloromethylation,
- phase transfer catalysis,
- piperonyl chloride
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