Citation:
LI Cheng-Zhou, GAN Xiao-Xian, QIU Shao-Jun, WANG Guang-Bi. Synthesis of 8-Chloro-4-(2-chloro-4-fluorophenoxy)quinoline Catalyzed by KF/Al2O3[J]. Chinese Journal of Applied Chemistry,
;2000, 17(6): 675-676.
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A facile method for the synthesis of title compound(CCFQ) in yield of 75% is reported. It is synthesized by reaction of 4,8-dichloroquin oline with 2-chloro-4-fluorophenol in the presence of KF/Al2O3. The product is confirmed by elemental analysis,1H NMR, IR and MS.
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Keywords:
- chloro(chloro-fluorophenoxy)quinoline,
- synthesis,
- KF/Al2O3
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