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Citation: YANG Dong-Zhi, LIU Xiao-Fei, LI Zhi, XU Huai-Yu, GUAN Yun-Lin, YAO Kang-De. On the Factors Influencing the Antibacterial Activity of Chitosan[J]. Chinese Journal of Applied Chemistry, ;2000, 17(6): 598-602. shu

On the Factors Influencing the Antibacterial Activity of Chitosan

1.
School of Material, Tianjin University, Tianjin 300072

Received Date: 31 December 1999
Available Online: 17 May 2000
Fund Project: 国家自然科学基金资助项目(59773002) (59773002)

The effects of concentration, deacetylation degree, molecular weight and pH of medium on the antibacterial activity of chitosan against Esherichia Coli have been investigated. The results showed that the antibacterial activity of chitosan increased with increase in concentration and deacetylation degree and it first increased with increasing molecular weight, reached a maximum at M_w=9.16×10.4 and pH=6.5 and then decreased with further increase in molecular weight. The effects of chitosan on the E.Coli was studied morphologically by confocal laser scanning microscopy and SEM with the results that the E.Coli cells were deformed and autolysed in contact with chitosan samples.
- chitosan,
- antibacterial activity,
- Esherichia Coli
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