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Citation: JIANG Zhong-Yi, JIA Qi-Peng, LIU Jia-Qi, CHEN Hong-Fang. Synthesis of Biologically Active Dipeptide in a Multiphase Enzyme Membrane Reactor[J]. Chinese Journal of Applied Chemistry, ;2001, 18(1): 56-58. shu

Synthesis of Biologically Active Dipeptide in a Multiphase Enzyme Membrane Reactor

1.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072

Received Date: 30 May 2000
Available Online: 4 September 2000
Fund Project: 国家自然科学基金资助课题(B29604) (B29604)

A multiphase enzyme membrane reactor using aqueous-organic biphase instead of water phase alone as the reaction medium was employed to investigate the lipase-catalyzed synthesis of bioactive dipeptides. The medium effect on dipeptide yield was first studied. When N-acetyl-L-phenylalanine ethyl ester(APEE) was used as a carboxyl component, the reactivity order of amino acid amides was found to be L-Leu-NH₂ >L-Val-NH₂ >L-Ala-NH₂ >L-Gly-NH₂. The didpetide, N-Ac-L-Phe-L-Leu NH₂, could be synthesized in the multiphase enzyme membrane reactor in a high yield and purity due to the simultaneous separation and reaction.
- lipase,
- multiphase membrane reactor,
- synthesis
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