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Citation: JI Ya-Fei, ZONG Zhi-Min, WEI Xian-Yong. Synthesis of 3,4,5-Trimethoxybenzaldehyde[J]. Chinese Journal of Applied Chemistry, ;2001, 18(7): 581-583. shu

Synthesis of 3,4,5-Trimethoxybenzaldehyde

1.
College of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008

Received Date: 22 August 2000
Available Online: 12 March 2001

3,4,5-Trimethoxybenzaldehyde was synthesized from p-cresol in an overall yield of 64 5%.p-Cresol was at first brominated and hydrolyzed to give 3,5-dibromo-4-hydroxybenzal-dehyde, which was methoxylated by methanolic sodium methoxide in the presence of cuprous chloride and dimethylformamide(DMF) at 125℃(ca.0.5 MPa) to provide sodium phenolate of 3,5-dimethoxy-4-hydroxybenzaldehyde, from which 3,4,5-trimethoxybenzaldehyde was obtained by methylation directly with dimethyl sulfate in aqueous sodium hydroxide."One-pot" method was used in the synthesis starting from economical, convenient and environmental awareness.
- trimethoxybenzaldehyde,
- p-cresol,
- synthesis
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