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Citation: LI Wan-Hu, LU Jun, Ma Huai-Rang. Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Lanthanum Chloride as a Catalyst[J]. Chinese Journal of Applied Chemistry, ;2001, 18(7): 566-568. shu

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Lanthanum Chloride as a Catalyst

1.
Department of Chemistry, Northwest University, Xi'an 710069

Received Date: 19 September 2000
Available Online: 10 January 2001
Fund Project: 陕西省自然科学基金(2000H03) (2000H03)西北大学科研基金(98NW07F)资助课题 (98NW07F)

An efficient one-pot synthesis method for 3,4-dihydropyrimidinones using lanthanum chloride heptahydrate as a catalyst by the reaction of aldehyde, U-keto ester and urea(in molar ratio 1:1:1.5) in ethanol is described.The method is simple and affords product in good yield(80%~90%).
- dihydropyrimidinone,
- Biginelli reaction,
- lanthanum heptahydrate,
- synthesis
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