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Citation: JIN Jian-Ming, LIU Xiu-Fang, XU Han-Sheng. Synthesis and Antitumor Activity of Glycyrrhetic Acid Derivatives[J]. Chinese Journal of Applied Chemistry, ;2001, 18(11): 869-872. shu

Synthesis and Antitumor Activity of Glycyrrhetic Acid Derivatives

1.
Department of Chemistry, Wuhan University, Wuhan 430072

Received Date: 29 March 2001
Available Online: 7 August 2001

Six new glycyrrhetic acid derivatives were synthesized from the reaction of di(2-chloroethyl)aminophosohonyl dichloride(4) with methyl glycyrrhetinate(1), methyl-11-deoxy glycyrrhetinate(2), and 3-U-30-dioxy-12-ene oleanane(3), respectively. Their structures were confirmed by MS, ¹H NMR and elemental analysis. The preliminary antitumor activity tests against EAC cells both in vitro and in rovo showed that the new compounds especially Ⅰ_a and Ⅰ_b exhibited a good antifumor activity in comparison with the nitrogen mustard.
- glycyrrhetinic acid,
- derivative,
- synthesis,
- antitumor activity
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