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Citation: ZHENG Yi-Ning, XIE Tian-Yao, MO Jin-Yuan, WEI Shou-Lian. Chiral Separation of Binaphthol Enantiomers by Capillary Electrophoresis Combined with Conductance Detection[J]. Chinese Journal of Applied Chemistry, ;2002, 19(2): 113-116. shu

Chiral Separation of Binaphthol Enantiomers by Capillary Electrophoresis Combined with Conductance Detection

1.
a Department of Chemistry, Zhongshan University, Guangzhou 510275;
2.
b Department of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning

Corresponding author: MO Jin-Yuan,
Received Date: 4 April 2001
Available Online: 20 September 2001
Fund Project: 国家自然科学基金(29675033) (29675033)广东省自然科学基金(001237)资助项目 (001237)

The binaphthol enantiomers were resolved by capillary electrophoresis combined with conductance detection. The U-cyclodextrin(U-CD) was used as a chiral reagent in sodium hydroxide solution. The Pt wire with diameter of 80 μm was used as working electrode. The separation parameters, such as concentration of running buffer and U-CD, applied voltage, have been studied in detail. Under the optimum conditions, baseline separation of the enantiomers could be completed in 15 minutes. The separation mechanism has been studied by using methylated U-CD as a chiral reagent. It was found that the H bonding is an important factor determining the interaction between molecules.
- capillary electrophoresis,
- conductance detection,
- binaphthol,
- isomer resolution
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