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Citation: LUO Tie-Jun, LI Zheng-Ming, WANG Su-Hua, LIAO Ren-An, LI Zhi-Chun. Synthesis of Halogen Substituted-2-(3-methyl-5- substitued-4H-1,2,4-triazol-4-yl)benzoic Acid[J]. Chinese Journal of Applied Chemistry, ;2002, 19(6): 594-596. shu

Synthesis of Halogen Substituted-2-(3-methyl-5- substitued-4H-1,2,4-triazol-4-yl)benzoic Acid

1.
a Hunan Institute of Chemical Industry, Changsha;
2.
b State Key Laburatory of Elernanto Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: LI Zheng-Ming,
Received Date: 15 November 2001
Available Online: 6 March 2002
Fund Project: 国家自然科学重点基金(29832050) (29832050)

The halogen substituted anthranilic acid(1) was condensed with acetic anhydride to give halogen substituted-3-methyl-1H-2,4-benoxazin-1-one(2), which was further condensed with hydrazide (3) to give twelve novel halogen substituted-2-(3-methyl-5-substitued-4H-1,2,4-triazol-4-yl) benzoic acid. All compounds synthesized were identified by ¹H NMR and elemental analyses.
- halogen substitued(methyl substitued-4H-triazol-yl)benzoic acid,
- anthranilic acid,
- triazole,
- condensation reaction
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