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Citation: LIAO Lian-An, LI Zheng-Ming, FANG Hong-Yun, ZHAO Wei-Guang, FAN Zhi-Jin, CHEN Ming-De, LIU Gui-Long. Synthesis and Bioactivity of 5-O-TPS-4"-O-carbonyl Avermectin B_1a[J]. Chinese Journal of Applied Chemistry, ;2002, 19(6): 521-526. shu

Synthesis and Bioactivity of 5-O-TPS-4"-O-carbonyl Avermectin B_1a

1.
a Department of Chemistry, Xiamen University, Xiamen;
2.
b Institute of Emento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: LI Zheng-Ming,
Received Date: 8 October 2001
Available Online: 1 March 2002
Fund Project: 国家自然科学基金重点基金资助项目(29832050) (29832050)

Ten 5-O-triphenylsilyl 4"-O-carbonyl Avermectin B_1a were prepared by esterification reaction of 5-O-triphenylsilyl Avermectin B_1a with corresponding carboxylic acids in the systems of 1,3-dicyclohexylcarbodiimide (DCC)/4-dimethylaminopyridine(DMAP) in good yield(55%~76%). Their chemical structures were confirmed by IR, ¹H NMR, ¹³C NMR and MS. The preliminary bioa-ssay results showed that some of the title compounds have good insecticidal activities against Aphis gossypii Glover and Tetranychus truncatus Ehara.
- Avermectin B_1a,
- esterification,
- dicyclohexylcarbodiimide/dimethylaminopyridine,
- bioactivity
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Synthesis and Bioactivity of 5-O-TPS-4"-O-carbonyl Avermectin B1a

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Synthesis and Bioactivity of 5-O-TPS-4"-O-carbonyl Avermectin B_1a