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Citation: WANG Ru-Lin, YANG Yu, SHUANG Shao-Min, PAN Jing-Hao. Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, ;2002, 19(7): 702-704. shu

Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives

1.
Department of Chemistry, Shanxi University, Taiyuan 030006

Corresponding author: SHUANG Shao-Min,
Received Date: 17 December 2001
Available Online: 26 April 2002
Fund Project: 国家自然科学基金(20172035) (20172035)

The inclusion interactions between flavonoids and U-cyclodextrin(U-CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1:1 inclusion compounds were formed beween U-CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A_L inclusion. U-CD derivatives have stronger binding capacity than U-CD. The enhanced solubility of compounds decreased in the order methyl-U-CD > hydroxypropyl-U-CD > U-CD. The highest solubility was obtained in methyl-U-CD inclusion complex with qucertin in level of 50 times than that in water.
- phase solubility,
- U-cyclodextrin and its derivatives,
- flavonoids,
- solubility
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