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Citation: LI Xi, LIU Yi, WU Jun, QU Song-Sheng. Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli[J]. Chinese Journal of Applied Chemistry, ;2002, 19(7): 645-648. shu

Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli

LI Xi ^a,b,, ,
LIU Yi ^b ,
WU Jun ^b ,
QU Song-Sheng ^b

1.
a State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070;
2.
b Department of Chemistry, Wuhan University, Wuhan

Corresponding author: LI Xi,
Received Date: 15 November 2001
Available Online: 28 January 2002
Fund Project: 国家自然科学基金(29973030)资助项目 (29973030)

The inhibitory or antibiotic actions of three kinds of the selenomorpholine derivatives on a strain of Escherichia coli have been studied by microcalorimetry. Differences in their abilities to inhibit the metabolism of this bacteria were observed. The extent and level of the inhibitory effect on the metabolism as judged by the rate constant, k, and the half-inhibitory concentration, IC₅₀, varied with the kinds of drugs. The rate constant(k) of Escherichia coli in the presence of the drugs was found decreased with the increase in concentration of the drug. The experimental results revealed that the antibiotic activity of selenomorpholines was in order of: N-dodecyl-selenomorpholine-acetyl methyl ester bromide > N-dodecyl-selenomorpholine > 4-selenomorpholine-formylethyl ester.
- selenomorpholine derivative,
- Escherichia coli,
- metabolism,
- inhibition,
- microcalorimetry
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