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Citation: SUN Gang-Chun, CHANG Jun-Biao, CHEN Rong-Feng, XIE Jing-Xi, CHENG Gui-Fang, WANG Liu-Fang, HE Juan, WANG Li-Min. Synthesis and Anti-inflammatory Activity of E,E-1-(3'-Indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one Derivatives[J]. Chinese Journal of Applied Chemistry, ;2002, 19(7): 621-624. shu

Synthesis and Anti-inflammatory Activity of E,E-1-(3'-Indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one Derivatives

1.
a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
2.
b Henan Provincial Institute of Chemistry, Zhengzhou;
3.
c Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

Corresponding author: WANG Liu-Fang,
Received Date: 15 November 2001
Available Online: 27 February 2002
Fund Project: 国家自然科学基金(29972009) (29972009)甘肃省自然科学基金(ZS991-A23-059-Y)资助项目 (ZS991-A23-059-Y)

Nine E,E-1-(3'-indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one derivatives were synthesized and characterized by MS, ¹H NMR and UV. Five of these compounds(1,3,4,6,7) showed a certain anti-inflammatory activity on mouse ear edema induced by croton oil with the inhibitions being 21.1%, 25.3%, 18.4%, 22.3% and 28.9% respectively (P<0.05 or P<0.01 vs control), at the hypodermic injection dose of 50 mg/kg.
- indole,
- pentadienone derivative,
- synthesis,
- anti-inflammatory activity
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