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Citation: LIU Guo-Dong, YAN Hu-Sheng, HE Bing-Lin, JIANG Gen-Hua, YANG Guo-Ying. Synthesis of Macroporous Acetyl Aminomethylene Polystyrene Resin and Its Application in Separation of Cystine and Tyrosine[J]. Chinese Journal of Applied Chemistry, ;2002, 19(9): 894-897. shu

Synthesis of Macroporous Acetyl Aminomethylene Polystyrene Resin and Its Application in Separation of Cystine and Tyrosine

1.
a State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071;
2.
b Tianjin Pharmaceutical Company, Tianjin

Corresponding author: YAN Hu-Sheng,
Received Date: 5 February 2002
Available Online: 17 May 2002
Fund Project: 天津市重点基金项目(983801411) (983801411)

Based on the fact that tyrosine molecule contains a phenyl ring and a phenolic hydroxyl group, a polymeric adsorbent-macroporous acetyl aminomethylene polystyrene resin, which was expected to form hydrogen bonding and hydrophobic interaction with tyrosine but not with cystine, was synthesized. The results indicated that tyrosine had high retention on a column packed with the adsorbent while cystine had no retention. By comparing the retentions of cystine, tyrosine and phenylalanine on columns packed with macroporous acetyl aminomethylene polystyrene resin, macro porous polystyrene resin and polyacrylamide resin, respectively, it was concluded that there are hydrophobic interaction and hydrogen bonding between tyrosine and macroporous acetyl aminomethylene polystyrene resin and the two interactions acted synergistically. From 0.4 g mixture of cystine and tyrosine, an industrial byproduct of amino acids from hydrolysis of proteins on a column(250 mm×10 mm, I.D.) packed with macroporous acetyl aminomethylene polystyrene resin 0.2 g of pure cystine and 0.12 g of pure tyrosine were obtained, respectively.
- acetyl aminomethylene polystyrene resin,
- tyrosine,
- cystine,
- separation,
- chromatography
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