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Citation: ZHAO Sheng-Yin, HUANG Wen-Long, ZHANG Hui-Bin, ZHOU Jin-Pei. Synthesis and Vasorelaxant Activity of Benzopyran-4-urea, -thiourea, and-cyanoguanidine Derivatives as K⁺ Channel Openers[J]. Chinese Journal of Applied Chemistry, ;2002, 19(12): 1128-1132. shu

Synthesis and Vasorelaxant Activity of Benzopyran-4-urea, -thiourea, and-cyanoguanidine Derivatives as K⁺ Channel Openers

1.
New Drug Research Center, China Pharmaceutical University, Nanjing 210009

Corresponding author: HUANG Wen-Long,
Received Date: 23 May 2002
Available Online: 11 September 2002
Fund Project: 国家自然科学基金资助项目(39370811) (39370811)

Seventeen benzopyran-4-urea, -thiourea and -cyanogunidine derivatives were synthesized as K⁺ channel openers. Their structures were confirmed by IR, ¹H NMR, MS and elemental analysis. Their vasorelaxant activities againat low (30 mmol/L) KCl-induced contraction were preliminary evaluated on rat aorta in vitro. Some compounds synthesized(7c, 8a, 8b and 8c) were found exhibited some, but less, low concentration K⁺(30 mmol/L KCl) channel opening activity than Emakalim.
- benzopyran,
- K⁺ channel opener,
- synthesis,
- vasorelaxant activity
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Synthesis and Vasorelaxant Activity of Benzopyran-4-urea, -thiourea, and-cyanoguanidine Derivatives as K+ Channel Openers

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通讯作者: 陈斌, bchen63@163.com

Synthesis and Vasorelaxant Activity of Benzopyran-4-urea, -thiourea, and-cyanoguanidine Derivatives as K⁺ Channel Openers