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Citation: LI Liang, LI Guo-Ming, LI Mao-Rong, RONG Pin-Jia. Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance[J]. Chinese Journal of Applied Chemistry, ;2003, 20(1): 65-68. shu

Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance

1.
Department of Chemistry, South China Normal University, Guangzhou 510631

Corresponding author: LI Guo-Ming,
Received Date: 19 June 2002
Available Online: 4 November 2002

Polylactic acid(PLA) microspheres(MS) were prepared by an oil-in-water solvent evaporation method to encapsulate rifampin(RFP). Effects of molecular weight of PLA, the drug content, microsphere size, pH value of medium on the drug-releasing performance of the PLA microspheres were investigated. The results showed that the greater the molecular weight of PLA, the less it degrades and the more slowly the drug release. Again, the greater the content of RFP and the greater the difference of drug concentration between in and out of the microsphere, the more quickly the drug releases. The smaller the microsphere size, the more quickly the drug releases. In the alkali medium, the PLA degrades more quickly, and RFP becomes more stable, resulting in the faster release of drug.
- polylactic acid,
- microsphere,
- refampin,
- drug release
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