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Citation: ZHANG Ai-Ying, LI Jie, FENG Zeng-Guo, ZHANG Yong. Preparation of Biodegradable Levonorgestrel Encapsulated Poly(ethyleneglycol)-b-Poly (butyleneterephthalate) Microspheres[J]. Chinese Journal of Applied Chemistry, ;2003, 20(3): 293-295. shu

Preparation of Biodegradable Levonorgestrel Encapsulated Poly(ethyleneglycol)-b-Poly (butyleneterephthalate) Microspheres

1.
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081

Corresponding author: FENG Zeng-Guo,
Received Date: 9 July 2002
Available Online: 17 December 2002
Fund Project: 国家"八六三"计划(2001AA216077)资助项目 (2001AA216077)

The behavior of poly (ethylene glycol)-b-poly(butylene terephthalate) copolymer has been investigated. The influences of the immersing time (in phosphate buffer solution of pH=7.4, at (37±1)℃) on the swelling ratio, the mass loss and the surface morphology of the copolymer film were examined. The copolymer is found to be degradable. The microspheres of PEG-b-PBT were prepared by a solvent extraction method using PVA as a stabilizer and characteristic of a smooth and spherical surface, sized about 1.133 μm. IR and XRD results reveal that Levonorgestrel crystalls are physically entrapped in the microspheres of the copolymer.
- poly (ethylene glycol)-b-poly (butylene terephthalate) copolymer,
- biodegradability,
- Levonorgestrel,
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