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Citation: HE Quan-Guo, LIU Zheng-Chun, ZHOU Ling-Jun, HE Nong-Yue, YANG Chun, LU Zu-Hong. Synthesis of Piperonol from Catechol[J]. Chinese Journal of Applied Chemistry, ;2003, 20(3): 281-283. shu

Synthesis of Piperonol from Catechol

1.
a Ministry of Education Key Laboratory for Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096;
2.
b College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing

Corresponding author: LU Zu-Hong,
Received Date: 6 August 2002
Available Online: 17 December 2002
Fund Project: 国家自然科学基金(60071001) (60071001)江苏省高新技术(BG2001010)资助项目 (BG2001010)

A facile synthesis of piperonol is reported from catechol. Reacted catechol with excess dichloromethane in an autoclave under nitrogen atmosphere gave 88.4% 1,3-benzodioxole (1), which is directly chloromethylated to yield 90.1% 5-chloromethyl 1,3-benzodioxole (2) by hydrogen chloride saturated triformol. 2 can easily convert to piperonal by treatment with alcoholic solution of Na₂CO₃ in yield of 97.7%. The total yield is 78%.
- piperonol,
- synthesis,
- catechol
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