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Citation:
LIU Xin-An, LI Wei, WANG Li-Ao. Preparation and Structure of Porous Spherical Hydroxyapatite Biomaterial[J]. Chinese Journal of Applied Chemistry,
;2003, 20(3): 223-227.
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A porous spherical hydroxyapatite (HA) ceramic biomaterial has been prepared directly by a simple chemical synthetic method followed by treatment with chitosan solution and calcination. The synthesized HA material of high purity consisted of a unique normal HA structure as confirmed by XRD and IR measurements.The size of fine spherical HA with most inner ducts linked up to each other for fresh bone to develop was well distributed between 400~700 μm by SEM observation. The mass ratio of Ca and P was about 1.67, close to that in human bone. The porous HA coated by polyactic acid (PLA) has been explored for drug delivery material using serum albumin as a model protein. A good result was obtained.
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Keywords:
- hydroxyapatite,
- serum albumin,
- drug delivery material
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