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Citation: ZHAO Jin-Hua, SUN Duo-Xian. Property of PACA-co-PEG Microparticles as Drug-carrier[J]. Chinese Journal of Applied Chemistry, ;2003, 20(5): 502-504. shu

Property of PACA-co-PEG Microparticles as Drug-carrier

ZHAO Jin-Hua ^a,b,, ,
SUN Duo-Xian ^a

1.
a School of Chemical Engineering, Tianjin University, Tianjin 300072;
2.
b Tianjin Pharmaceutical Co.Ltd., Tianjin 300161

Corresponding author: ZHAO Jin-Hua,
Received Date: 18 September 2002
Available Online: 30 January 2003

Amphithatic polymeric microparticles were prepared from copolymers of poly (alkyl cyanoacrylate) (PACA) and poly (ethylene glycol) (PEG) (PACA-co-PEG) by evaporation method.And drug-loaded copolymeric microparticles were formed by mixing polymeric microparticles with paracetamol (PCTM) as a simulated drug.The polymeric microparticles are round shaped with outer diameter <200 nm as determined by dynamic light scattering and transmission electron microscopy.The degradation rate of PECA-co-PEG was less than that of homopolymer PECA;while degradation rate of PECA was larger than that of PBCA (PECA:polyethyl cyanoacrylate;PBCA:polybutyl cyanoacrylate).
- poly(alkyl cyanoacrylate),
- microparticle,
- drug carrier,
- biodegradable
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