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Citation: JIANG Yin-Zhi, HU Wei-Xiao. Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co²⁺, Ni²⁺, Fe³⁺ and Zn²⁺[J]. Chinese Journal of Applied Chemistry, ;2003, 20(6): 582-585. shu

Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co²⁺, Ni²⁺, Fe³⁺ and Zn²⁺

JIANG Yin-Zhi ,
HU Wei-Xiao ^,

1.
Department of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: HU Wei-Xiao,
Received Date: 5 November 2002
Available Online: 6 March 2003
Fund Project: 浙江省自然科学基金(200016)资助项目 (200016)

2-Acetyl-pyridin ketazine and its complexes with Co²⁺,Ni²⁺,Fe³⁺,Zn²⁺ were synthesized respectively by refluxing it with conresponding salts [FeCl₃,CoCl₂,Ni(NO₃)₂,ZnCl₂].The compositions and structures of the ligand and complexes have been characterized by the elemental analysis,IR spectra and UV spectra.Their inhibiting actions on the superoxide anions were examined by using nitroblue tetrazolium (NBT) method.Their bioactivities against P388-leucocythemia for rats were tested by using methyl-thiazoltetrazolium (MTT) method and against A-549 human lung cancer cells by sulforhodamine B(SRB) method,both in vitro.The ligand and all of the complexes were found to be bioactive,while Co-and Nicomplexes showed greater activities and Fe- and Zn-complexes were weaker than the ligand.It is deduced that the activities of the complexes may depend on the structure of the outermost d-orbital electrons.
- ketazine,
- transition metal complex,
- synthesis,
- O₂^- inhibition,
- leucocythemia,
- lung cancer
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Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co2+, Ni2+, Fe3+ and Zn2+

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Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co²⁺, Ni²⁺, Fe³⁺ and Zn²⁺