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Citation: ZHONG Bin, ZHAO Wei-Guang, LI Zheng-Ming, WANG Su-Hua. Synthesis of 3-N-Acetyl-2-substituted phenyl-5-[5'-Methyl-Isoxazole-3'-yl]-Δ₃-1,3,4-Oxadiazoline[J]. Chinese Journal of Applied Chemistry, ;2003, 20(8): 719-722. shu

Synthesis of 3-N-Acetyl-2-substituted phenyl-5-[5'-Methyl-Isoxazole-3'-yl]-Δ₃-1,3,4-Oxadiazoline

1.
Joint Institute of Nankai University and Tianjin University, State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: LI Zheng-Ming,
Received Date: 18 December 2002
Available Online: 31 March 2003
Fund Project: 国家"八六三"(2001AA235011)项目 (2001AA235011)

5-Methyl-isoxazole-3-formylhydrazine 2 was prepared by hydrazinolysis of the corresponding ester 1. Condensation of 2 with appropriate aldehydes produced corresponding hydrazones(3a~3h). Cyclization of (3a~3h) with acetic anhydride gave the title compounds in good yields. Structures of the intermediates and products were confirmed by means of ¹H NMR, MS and elemental analyses.
- methyl-isoxazole-formylhydrazine,
- oxadiazoline,
- synthesis
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Synthesis of 3-N-Acetyl-2-substituted phenyl-5-[5'-Methyl-Isoxazole-3'-yl]-Δ3-1,3,4-Oxadiazoline

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通讯作者: 陈斌, bchen63@163.com

Synthesis of 3-N-Acetyl-2-substituted phenyl-5-[5'-Methyl-Isoxazole-3'-yl]-Δ₃-1,3,4-Oxadiazoline