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Citation: XIONG Jun-Ru, XIANG Qing-Xiang, ZHANG Yuan-Qin. Synthesis and Mesomorphism of 3,6-Disubstituted Pyridazines[J]. Chinese Journal of Applied Chemistry, ;2003, 20(11): 1088-1092. shu

Synthesis and Mesomorphism of 3,6-Disubstituted Pyridazines

1.
Department of Environment and Life Science, Leshan Teacher's College, Leshan 614004

Corresponding author: XIONG Jun-Ru,
Received Date: 12 April 2003
Available Online: 15 August 2003
Fund Project:

Eight 3-alkoxy-6-(4-cholesteryloxycarbonylphenyl) pyridazines containing a pyridazine ring, a benzene ring, a cholesteryl, an ester group and an alkoxyl group of different length were synthesized through the cross-coupling reaction of 3-chloro-6-alkoxypyridazines and p-cholesteryloxycarbonylphenylboronic acid in the presence of palladium catalyst. The reaction of 3,6-dichloropyridazine with the alcohol under phase transfer catalyst gives 3-chloro-6-alkoxypyridazine. Their mesomorphism was studied by differential scanning calorimetry. The results showed that seven compounds have mesomorphism. The length of the terminal chain could affect the phase transition and clearing point temperatures of the compounds, but it has little influence on the temperature range of mesomorphous phases.
- pyridazine derivative,
- synthesis,
- mesomorphism
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