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Citation: YANG Kang-Lin, LI Xin-Sheng, ZHANG Ling, CHEN Yi-Lang, DENG Rui-Hong. Synthesis of Some Medicine Compounds Containing Germanium Moiety and Their Anticancerous Activity[J]. Chinese Journal of Applied Chemistry, ;2004, 21(1): 101-103. shu

Synthesis of Some Medicine Compounds Containing Germanium Moiety and Their Anticancerous Activity

1.
Department of Chemistry, Nanchang University, Nanchang 330047

Corresponding author: LI Xin-Sheng,
Received Date: 25 March 2003
Available Online: 30 September 2003

The GeCl₃, Ge(OH)₃, GeO₃ and GeO_1/2 moieties have been introduced to sulfonyldianiline, carbamazepine and norfloxacin, respectively, to give four medicines containing germanium. The structures of the medicines prepared were characterized by IR, ¹H NMR and elemental analysis. The biological tests showed that the new compounds have anticancerous activity, among them the compound prepared from sulfonyldianiline(2000-1) has inhibitory rate of 88.6% at dosage of 1×10^-4 mol/L.
- germanium,
- sulfonyldianiline,
- carbamazepine,
- norfloxacin,
- anticancer
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