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Citation: HE Qiang-Fang, LI Guo-Ming, WU Hai-Zhen, LU Zhi-Min, LI Liang. Preparation and Drug Releasing Property of 5-Fluorouracil-loaded Chitosan Microsphere[J]. Chinese Journal of Applied Chemistry, ;2004, 21(2): 192-196. shu

Preparation and Drug Releasing Property of 5-Fluorouracil-loaded Chitosan Microsphere

1.
Departmengt of Chemistry, South China Normal University, Guangzhou 510631

Corresponding author: LI Guo-Ming,
Received Date: 15 May 2003
Available Online: 10 August 2003

5-Fluorouracil(5-Fu) chitosan(CS) microspheres were prepared in emulsion by using glutaradelhyde as cross-linking agent, span-80 and magnesium stearate mixture as emulsifer and vacuum-pump oil-paraffin oil mixture as oil phase. 5-Fu encapsulated capacity was of 43.6%~84.8%, one to several times higher than that reported in literatures(about 15.1%). Drug releasing property of 5-Fu/CS capsules was studied in the phosphate buffer(pH=7.4) and citrate buffer(pH=3.9) solutions. The results showed that m(5-Fu)/m(CS), amount of cross-linking agent and the pH value of media all affected the releasing of 5-Fu from microspheres. The drug releasing rate was found decreased with m(5-Fu)/m(CS) and increased with n(CHO)/n(NH₂). The drug releasing performance was better in the acid media than in the alkali one. The IR results indicated there was a strong molecular interaction between 5-Fu and chitosan. SEM images show the 5-Fu-CS microspheres are spherical shape with diameters ranged from 1~5 μm.
- chitosan,
- fluorouracil,
- microsphere,
- drug releasing
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