Citation:
DENG Lian-Dong, SUN Duo-Xian, YAO Fang-Lian, HUO Jian-Zhong, DONG An-Jie. Preparation of Methoxypolyethylene glycol-b-poly(D,L-lactic acid) Nanomicelles[J]. Chinese Journal of Applied Chemistry,
;2004, 21(3): 247-250.
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Amphiphilic diblock copolymers(PEDLLA) were synthesized from D,L-lactic acid and methoxy-polyethylene glycol by meltingpolycondensation. PEDLLA nanomicelles were prepared by nanoprecipitation technique and characterized by DLS, 1H NMR, pyrene monomer probe fluorescence technology and UV spectrometry. Micelles obtained were of core-shell structure and nano sized. The size of micelles was influenced by the molecular weight of polyactic acid(PDLLA) segment and PEDLLA concentration in organic solvent. The critical micelle concentrations of PEDLLA were less than 2.43×10-6 mol/L and decreased with increase in the molecular weight of PDLLA segment.
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